Status:
COMPLETED
The Treatment of Hepatocirrhosis and Portal Hypertension
Lead Sponsor:
Yanjing Gao
Collaborating Sponsors:
Shandong Provincial Hospital
Jinan Military General Hospital
Conditions:
Hepatic Cirrhosis
Portal Hypertension
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
This study compare the efficiency of partial splenic embolization +endoscopical therapy with endoscopical therapy alone in gastroesophageal variceal haemorrhage accompanied with splenomegaly or hypers...
Detailed Description
Endoscopic therapy is the mature treatment of gastroesophageal variceal haemorrhage and PSE is an effective method for treatment of the hypersplenism and portal hypertension. Existing researches show ...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients aged between 18 and 75 years
- Patients who had recovered from an episode of VH or patients who had survived from acute VH and there was no bleeding for consecutive 5 days
- Patients with a diagnosis of liver cirrhosis and portal hypertension on clinical examination, laboratory test, and imaging or histological examination
- Patients with hypersplenism and thrombocytopenia (platelets \< 100,000/µL).
- Exclusion criteria :
- Previous therapy (splenectomy, PSE, EVL, tissue adhesive injection, or usage of (NSBB) to prevent rebleeding
- Bleeding from isolated gastric or ectopic varices
- Hepatocellular carcinoma or other malignant tumors
- Contraindications for the use of NSBBs, hepatic failure, and Child-Pugh class C with large amount ascites, or grade 3-5 hepatic encephalopathy, or prothrombin activity ≤ 40%
- Hepatic failure
- Contraindications for PSE
- Pregnancy and lactation
- Inability to sign the informed consent.
Exclusion
Key Trial Info
Start Date :
February 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT02778425
Start Date
February 1 2016
End Date
January 1 2020
Last Update
February 14 2025
Active Locations (1)
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1
Department of Gastroenterology,Qilu Hospital,Shandong University
Jinan, Shandong, China, 250012