Status:
COMPLETED
CPT-fMRI Study for PTSD
Lead Sponsor:
University of Manitoba
Collaborating Sponsors:
Workers Compensation Board of Manitoba
Conditions:
Stress Disorders, Post-Traumatic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Posttraumatic stress disorder (PTSD) is prevalent mental illness (\~9% life-time) that results from exposure to trauma. As it is associated with vastly heterogeneous origins, accurate diagnosis and op...
Detailed Description
Posttraumatic stress disorder (PTSD) develops when a constellation of symptoms persist following exposure to traumatic events such as actual or threatened death, serious injury, and sexual violation, ...
Eligibility Criteria
Inclusion
- INCLUSION PTSD
- Current diagnosis of PTSD as assessed by the Clinician Administered PTSD Scale (CAPS) for the DSM-V \[30\]; CAPS ≥ 15
- Presence of at least one intrusion symptom, two negative cognition and mood symptoms, and two arousal symptoms.
- Trauma Exposed Controls
- experienced a traumatic event (as assessed by criterion A of the CAPS)
- CAPS \< 15 Health Controls
- 1\. Not experienced a traumatic event (as assessed by criterion A of the CAPS ≤15)
- EXCLUSION All
- substance dependence not in remission for at least three months
- current uncontrolled bipolar or psychotic disorder, or severe cognitive impairment.
- Contraindications for MRI (e.g., no metal implants, not pregnant)
Exclusion
Key Trial Info
Start Date :
October 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2022
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03229915
Start Date
October 1 2017
End Date
September 30 2022
Last Update
February 15 2023
Active Locations (1)
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1
University of Manitoba
Winnipeg, Manitoba, Canada, R3E 0J9