Status:
COMPLETED
Patterns of Neurocircuitry Activation In Severe Asthma
Lead Sponsor:
University of Wisconsin, Madison
Collaborating Sponsors:
National Institutes of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Lung Diseases
Eligibility:
All Genders
18+ years
Brief Summary
The overall purpose of the study is to compare the patterns of neurocircuitry activation in severe asthmatics vs. mild to moderate and healthy controls. The Investigators hypothesize that neurocircuit...
Detailed Description
To begin to further address possible relationships of asthma and brain function, the investigators propose the following hypothesis, "patients with defined characteristics of severe asthma will have d...
Eligibility Criteria
Inclusion
- Currently enrolled in Severe Asthma Research Program III (2012-0571) study
- Has severe asthma
- Is a male or female with no health concerns that might affect the outcome of the study
- Provided a negative urine pregnancy test prior to visit (Females only)
- Capable and willing to grant written informed consent and cooperate with study procedures and requirements (investigator discretion)
- Is able to tolerate a simulated functional Magnetic Resonance Imaging brain scanning session
- Is able to give valid informed consent to participate by signing and dating a written consent form
Exclusion
- Uses psychotropic medication that might affect function of neurocircuitry implicated in our hypotheses (at the discretion of a study physician or Co-Investigator)
- Has one or more contraindications for functional Magnetic Resonance Imaging
- Has needle phobia or claustrophobia
- Unable to distinguish specific colors used in Stroop task
- History of a diagnosed Bipolar Disorder, Schizophrenia, or Schizoaffective Disorder
- Is a pregnant or lactating female
- Has had an upper or lower respiratory infection within 1 month of the visit
- Has unstable asthma as indicated by self-report of increased symptoms or increased beta-agonist use over the 2 weeks preceding the visit
- Is a current smoker (defined as smoked within the last year) or a former smoker with a history of \>5 pack years
- Any condition which, in the opinion of the investigator, might interfere with participation in the study
- Inability or unwillingness to perform required study procedures
Key Trial Info
Start Date :
August 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 17 2018
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT03230188
Start Date
August 1 2017
End Date
June 17 2018
Last Update
January 24 2019
Active Locations (1)
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1
UW Madison
Madison, Wisconsin, United States, 53792