Status:
COMPLETED
Effects and Mechanism of Two Hybrid Exercise-cognitive Trainings in Mild Ischemic Stroke With Cognitive Decline
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Stroke Patients With Cognitive Decline
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The purposes are to: (1) examine and compare the effects of two hybrid interventions on brain plasticity, physiological biomarkers and behavioral outcomes, including cognitive and physical functions, ...
Detailed Description
Cognitive decline after stroke is highly associated with functional disability. Empirical evidence shows that exercise combined cognitive training may induce neuroplastic changes that modulate cogniti...
Eligibility Criteria
Inclusion
- Stroke occurring at least 6 months prior to enrollment
- Age range from 20 to 80 years
- MMSE score \< 28 or MoCA\<25
- Able to follow the study instruction
- Adequate cardiopulmonary function to perform aerobic exercise
- Able to walk with or without assistive devices
Exclusion
- Unstable medical history (e.g., recent myocardial infarction) that might limit participation
- Concomitant with other neurological disorders (e.g., Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis)
- Current participation in another interventional trial
- Any contraindication to MRI (metallic implants, claustrophobia, seizure, pacemakers, et al)
- Pregnant woman
Key Trial Info
Start Date :
April 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 31 2020
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT03230253
Start Date
April 19 2018
End Date
July 31 2020
Last Update
October 26 2020
Active Locations (1)
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1
Kaohsiung Municipal Siaogang Hospital
Kaohsiung City, Taiwan, 812