Status:
UNKNOWN
FMT Treating Constipation Patients With Depression and/or Anxiety Symptoms - Clinical Efficacy and Potential Mechanisms
Lead Sponsor:
Jianfeng Gong
Conditions:
Constipation - Functional
Depressive Symptoms
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Constipated patients often have mental problems such as depression and anxiety due to difficult defecation. Our previous studies have proved the efficacy of FMT treating constipation. Meanwhile it is ...
Eligibility Criteria
Inclusion
- Patients who were diagnosed as functional constipation (FC) according to Rome Ⅳ criteria were enrolled.
- Age ≥ 18 years
- Body mass index of 18-25 kg/m2.
- HAMA ≥ 14 and/or HAMD (17 items) ≥ 17
Exclusion
- History of sever mental disorders such as schizophrenia and bipolar disorder
- History of organic intestinal disorders
- History of gastrointestinal surgery
- Pregnant or breast-feeding women
- Infection with enteric pathogen
- Usage of probiotics, prebiotics, antibiotics within the last month
- Uncontrolled hepatic, renal, cardiovascular, and respiratory, or any diseases that in the opinion of the investigator, could affect intestinal transit and the intestinal microbiota.
- Patients who could not complete the follow-up
Key Trial Info
Start Date :
July 30 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03233100
Start Date
July 30 2017
End Date
December 31 2018
Last Update
July 28 2017
Active Locations (1)
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1
Department of Generay Surgery, Jinling hosptal, Medical School of Nanjing University
Nanjing, Jiangsu, China, 210000