Status:
ACTIVE_NOT_RECRUITING
PET Imaging of Chronic Pain Syndromes
Lead Sponsor:
Thomas Jefferson University
Conditions:
Chronic Pain Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
Central nervous system (CNS) changes associated with pain have been difficult to measure until the development of functional neuroimaging techniques such as positron emission tomography (PET). We have...
Detailed Description
The proposed study is based on our growing understanding of chronic pain and our ability to use functional brain imaging to study in vivo neurophysiologic processes. It is important to understand the ...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Chronic Pain Patients:
- Age greater than 18 years old.
- Have chronic pain symptoms for \>3 months;
- Have moderate pain (\>3/10) in 2 or more areas for more than 5 out of 7 days
- Is planning on undergoing chiropractic care for the clinical management of the chronic pain.
- May be on pain medications provided that they are on a stable dose for at least 1 month
- Patients have no other pre-existing and active significant medical, neurological, or psychological disorders.
- Minor, stable health problems that should have no substantial effect on cerebral blood flow will be allowed (i.e. controlled hypertension, medication controlled diabetes).
- Patients will be allowed to be taking medications or supplements at the initial intake, but they must be on a stable dose regimen for at least 1 month.
- Able to give informed consent and willing to complete the study at Thomas Jefferson University and Marcus Institute of Integrative Health.
- Inclusion Criteria for Healthy Controls:
- No significant current active medical conditions.
- Stable medical conditions as determined by the PI are allowed.
- No brain or body abnormalities that would affect the acquisition or analysis of the scan.
- Exclusion Criteria for Chronic Pain Patients and Healthy Controls:
- Pregnant or breast feeding
- Enrollment in active clinical trial/ experimental therapy within the prior 30 days.
- Subject is unable or unwilling to lie still in the scanner (i.e. due to claustrophobia or weight)
- Subject has metal in their body or other reason that they cannot undergo magnetic resonance imaging.
Exclusion
Key Trial Info
Start Date :
June 7 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2026
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT03233594
Start Date
June 7 2017
End Date
April 1 2026
Last Update
July 25 2025
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Thomas Jefferson University, Marcus Institute of Integrative Health Centers
Philadelphia, Pennsylvania, United States, 19107
2
Thomas Jefferson University, Marcus Institute of Integrative Health Centers
Villanova, Pennsylvania, United States, 19085