Status:
RECRUITING
Retinal Imaging in Neurodegenerative Disease
Lead Sponsor:
Duke University
Collaborating Sponsors:
University of Edinburgh in Scotland
Tan Tock Seng Hospital in Singapore
Conditions:
Alzheimer's Disease
Mild Cognitive Impairment
Eligibility:
All Genders
18+ years
Brief Summary
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the st...
Detailed Description
Using a multidisciplinary approach, this study aims to yield new insight into the vascular and structural pathophysiology of neurodegenerative disease. The investigators propose to develop and evaluat...
Eligibility Criteria
Inclusion
- Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
- Adults without neurodegenerative disease
Exclusion
- Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
- Eyes that have had intraocular surgery, other than cataract surgery.
- If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.
Key Trial Info
Start Date :
July 20 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
2000 Patients enrolled
Trial Details
Trial ID
NCT03233646
Start Date
July 20 2017
End Date
December 31 2025
Last Update
January 27 2025
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27705