Status:
UNKNOWN
Constitutional Genetics in Follicular Lymphoma
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Follicular Lymphoma
Genetic Predisposition to Disease
Eligibility:
All Genders
18+ years
Brief Summary
Follicular lymphoma is the second most common adult B-cell lymphoma. The acquisition of the t(14;18) translocation is the genetic hallmark of Follicular lymphoma. However, 50% to 70% of healthy indivi...
Eligibility Criteria
Inclusion
- Group "Genome Wide Association Studies"
- Follicular lymphoma treated in first line therapy treated by immunochemotherapy (PRIMA, FOL05, MER1 and 2, control arm of RELEVANCE trial)
- Follicular lymphoma treated in first line therapy by Rituximab and Lenalidomide as part of the investigational arm of RELEVANCE trial
- Available constitutional DNA samples for GWAS analysis with an accurate consent form for such genetic study
- Available biological and clinical characteristics at diagnosis with a follow-up of the patient for event free survival analysis
- 18 years of age or older
Exclusion
- A non-follicular lymphoma histology according to WHO 2016 classification (grade 1, 2, 3a follicular lymphoma)
- Relapsed follicular lymphoma
- Patients without an accurate consent form for constitutional genetic study
- Patients with no available biological or clinical data and follow-up for the outcome analysis
- Group "EPIC"
- Inclusion Criteria:
- Included in the EPIC Cohort (European Prospective Investigation into Cancer and nutrition study between 1992 and 2000)
- Available constitutional DNA samples with an accurate consent form for such genetic study
- 18 years of age or older
Key Trial Info
Start Date :
November 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2019
Estimated Enrollment :
1883 Patients enrolled
Trial Details
Trial ID
NCT03234140
Start Date
November 1 2017
End Date
November 1 2019
Last Update
July 31 2017
Active Locations (1)
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1
Service d'Hématologie Clinique, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon
Pierre-Bénite, France, 69495