Status:
COMPLETED
Preventing Hypertension and Sympathetic Overactivation by Targeting Phosphate
Lead Sponsor:
University of Texas Southwestern Medical Center
Conditions:
Hypertension
Eligibility:
All Genders
18-80 years
Phase:
PHASE2
Brief Summary
An increasing number of studies have indicated that most fast food and common grocery items, contain large amount of inorganic phosphate-based food additives , which are highly absorbable. The long-te...
Detailed Description
Animal studies suggest that high phosphate diet raises blood pressure but the mechanism underlying this phenomenon is not known. To study the effect of high phosphorus diet on blood pressure in humans...
Eligibility Criteria
Inclusion
- (answer must be yes to all to enter trial; check yes or no)
- º ≥ 18 years of age
- º Stage 1 Prehypertension (office BP 120-129/80-84 mmHg and normal ABPM \<130/80)
Exclusion
- (answer must be no to all to enter trial)
- º Diabetes mellitus or other systemic disease
- º Cardiopulmonary disease
- º Treatment with antihypertensive medications
- º eGFR\< 60 ml/min/1.73m2
- º Pregnancy
- º Hypersensitivity to nitroprusside or phenylephrine
- º Psychiatric illness
- º H/o substance abuse or current smoker
- º H/o malignancy
- º Serum Phos \<2.4 mg/dL or \>4.5 mg/dL
Key Trial Info
Start Date :
October 16 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2022
Estimated Enrollment :
94 Patients enrolled
Trial Details
Trial ID
NCT03234361
Start Date
October 16 2017
End Date
September 30 2022
Last Update
November 4 2022
Active Locations (2)
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1
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75390
2
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390