Status:
UNKNOWN
Use of Nitroglycerine to Improve Signs of Poor Peripheral Perfusion in Patients With Traumatic Hemorrhagic Shock
Lead Sponsor:
Assiut University
Conditions:
Hemorrhagic Shock
Eligibility:
All Genders
20-60 years
Phase:
PHASE2
Brief Summary
Hemorrhagic shock is a pathologic state in which intravascular volume and oxygen delivery are impaired. During circulatory failure associated with hypovolemia and low cardiac output, redistribution of...
Detailed Description
Perfusion index (PI) is a non-invasive numerical value of peripheral perfusion obtained from pulse oximetry, it is an indicator of the pulse strength at the sensor site. The PI's values range from 0.2...
Eligibility Criteria
Inclusion
- Age: 20-60 years old. With the patient fully conscious or slightly drowsy.
- Blood pressure: Systolic blood pressure below 90mmhg ,mean blood pressure below70mmhg or decrease of systolic blood pressure 40mmhg below normal value.
- Metabolic acidosis: PH less than 7.35 due to hypoperfusion.
- Capillary refill time \> 4 seconds.
- Normal body core temperature.
Exclusion
- Age: below 20 and above 60 years old.
- Head trauma with Glasco coma score below 14 due to increased intracranial pressure (stroke, subarachnoid hemorrhage or brain trauma injury).
- Severe hypotension not responding to fluid therapy.
- Patient with bilateral ischemic arm injury.
- Patient with hepatic cell failure
- Patients admitted to the emergency trauma department after 6 hours of the trauma event.
- Preexisting conditions as severe cardiovascular disease, uncontrolled hemorrhage, failure of central venous catheterization, dialytic procedure anticipated during the study period.
Key Trial Info
Start Date :
March 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03235921
Start Date
March 1 2016
End Date
October 1 2017
Last Update
August 1 2017
Active Locations (2)
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1
Assuit University Hospital
Asyut, Egypt
2
Assuit University Hospital
Asyut, Egypt