Status:
TERMINATED
Intravenous Subdissociative-dose Ketamine Versus Morphine for Prehospital Analgesia
Lead Sponsor:
Nantes University Hospital
Conditions:
Pain Management
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
This is a prospective, randomized, single-blind trial evaluating prehospital patients experiencing moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. Pa...
Detailed Description
This study is designed to evaluate if ketamine alone is non inferior to morphine alone for prehospital analgesia. Numeric rating scale pain scores will be compared between recipients of ketamine and r...
Eligibility Criteria
Inclusion
- older than 18 years old
- prehospital moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5
Exclusion
- unstable vital signs (systolic blood pressure \<90 or \>200 mm Hg, pulse rate \<50 or \>150 beats/min, and respiration rate \<10 or \>30 breaths/min)
- pregnancy
- breast-feeding
- altered mental status
- unable to give numeric rating scale scores
- allergy to morphine or ketamine
- acute pulmonary edema
- acute coronary syndrome
- renal or hepatic insufficiency
- patient who received morphine for the same acute pain
- acute psychiatric illness
Key Trial Info
Start Date :
November 23 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 26 2022
Estimated Enrollment :
285 Patients enrolled
Trial Details
Trial ID
NCT03236805
Start Date
November 23 2017
End Date
November 26 2022
Last Update
December 21 2022
Active Locations (12)
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1
Angers University Hospital
Angers, France, 49100
2
University Hospital of Bordeaux
Bordeaux, France, 33000
3
Hospital of Chateaubriant
Châteaubriant, France, 44146
4
CH de Gonesse
Gonesse, France, 95500