Status:
COMPLETED
Poor Ovarian Responders Undergoing IVF Using Luteal Ovarian Stimulation Versus Follicular Ovarian Stimulation
Lead Sponsor:
Kaohsiung Veterans General Hospital.
Conditions:
Fertilization in Vitro
Eligibility:
FEMALE
30-45 years
Phase:
NA
Brief Summary
The investigators attempted to compare the clinical outcomes and cumulus genes expression in poor ovarian responders undergoing luteal ovarian stimulation or follicular ovarian stimulation in in vitro...
Detailed Description
Multiple follicular wave theory proposed by Baerwald et al. implied that follicle recruitment may occur in the luteal phase of menstrual cycle. Therefore, luteal phase ovarian stimulation (LPOS) was c...
Eligibility Criteria
Inclusion
- Poor ovarian responders (PORs) met the Bologna criteria, having at least two of the three following features:
- advanced maternal age (≥ 40 years) or any other risk factor for POR,
- a previous POR (≤ 3 oocytes with a conventional stimulation protocol), and
- an abnormal ovarian reserve test. An abnormal ovarian reserve test was defined as antral follicle count (AFC) \< 5 or anti-Müllerian hormone (AMH) \< 1 ng/mL in this study.
- Moreover, two episodes of a previous POR after maximal stimulation alone would be sufficient to define a patient as a POR.
Exclusion
- oophorectomy
- exposure to cytotoxic or pelvic irradiation for malignancy
- taking herbal drugs or other hormonal agents
Key Trial Info
Start Date :
May 3 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT03238833
Start Date
May 3 2017
End Date
December 31 2019
Last Update
February 18 2021
Active Locations (1)
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1
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan, 81362