Status:
COMPLETED
The Effects of Spinal Anesthesia on ED50 and BIS50 of Etomidate for the Loss of Consciousness
Lead Sponsor:
General Hospital of Ningxia Medical University
Conditions:
Dose-Response Relationship, Drug
Eligibility:
FEMALE
18-65 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the effect of spinal anesthesia on ED50 and BIS50 of etomidate for the loss of consciousness (LOC) by using up-and-down method.The hypothesis was that spina...
Detailed Description
The combination of spinal with general anesthesia has been demonstrated to provide many clinically relevant advantages, however, this technique often experiences hypotension and bradycardia in the ind...
Eligibility Criteria
Inclusion
- ASA physical status I-II
- Body mass index (BMI) between 18.0 and 24.5 kg/m2
- Undergoing short elective laparotomy procedures, hysteroscopic and vaginal operation
Exclusion
- Contraindication to spinal anesthesia
- Hearing loss
- History of cardiovascular disease, psychiatric and central nervous system diseases
- Hepatic or renal dysfunction
- Severe diabetes or hyperkalemia
- History of drug and alcohol abuse
- An allergy to amide local anesthetics or etomidate
- Adrenocortical hypofunction
Key Trial Info
Start Date :
June 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 15 2017
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT03240055
Start Date
June 1 2017
End Date
July 15 2017
Last Update
September 6 2017
Active Locations (1)
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1
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China, 750004