Status:
UNKNOWN
Personalized Prediction Strategy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Lead Sponsor:
Guangzhou Institute of Respiratory Disease
Collaborating Sponsors:
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou Science and Technology Innovation Commission,China
Conditions:
Pulmonary Disease, Chronic Obstructive
Eligibility:
All Genders
40+ years
Brief Summary
This is a 3 year longitudinal study to establish a personalized prediction and prevention system for acute exacerbation of chronic obstructive pulmonary disease（AECOPD). Data will be collected which c...
Eligibility Criteria
Inclusion
- Patients was diagnosed as COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines older than 40 years old.
- A signed and dated written informed consent is obtained prior to participation.
- Able to comply with the requirements of the protocol and be available for study visits over 3 years.
Exclusion
- A COPD subject will not be eligible for inclusion in this study if any of the following criteria apply:
- Known respiratory disorders, or disorders identified at screening/visit 1 (including identification on the first CT scan), other than COPD (e.g.: lung cancer, sarcoidosis, tuberculosis, lung fibrosis, cystic fibrosis)
- Known history of significant inflammatory disease, other than COPD (e.g. rheumatoid arthritis and Lupus)
- Known to be severely alpha-1-antitrypsin deficient
- Has experienced a moderate or severe exacerbation (requiring oral corticosteroid, antibiotics or hospitalisation) within the last 4 weeks
- Having undergone lung surgery (e.g. lung reduction, lung transplant)
- Have cancer or have had cancer in the 5 years prior to study entry
- Having received a blood transfusion in the 4 weeks prior to study start
- Inability to walk
- Taking part in a blinded drug study
- Having therapy with systemic corticosteroids at inclusion.
Key Trial Info
Start Date :
August 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2021
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT03240315
Start Date
August 1 2016
End Date
September 1 2021
Last Update
February 9 2021
Active Locations (1)
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1
Guangzhou Institute of Respiratory Health,The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China, 510120