Status:
COMPLETED
PRIME: Cognitive Outcome Following Major Burns
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Collaborating Sponsors:
University of Westminster
Imperial College Healthcare NHS Trust
Conditions:
Cognitive Dysfunction
Burns
Eligibility:
All Genders
18+ years
Brief Summary
PRIME aims to demonstrate through neurocognitive assessment that BICU patients will have a degree of neurocognitive dysfunction following a major burn, that this neurocognitive dysfunction is due to a...
Detailed Description
Patients were matched with for age, sex and IQ (as determined by National Adult Reading Test scores) controlled volunteers. Participants were assessed for the following domains: verbal ability, verba...
Eligibility Criteria
Inclusion
- Invasive ventilation on a Burns Intensive Care Unit (BICU) within the previous ten years
- Burn injuries greater than 15% total body surface area (TBSA)
- Adult
Exclusion
- Admission to BICU for other illnesses that were not burn related (such as Toxic Epidermal Necrolysis Syndrome)
- Evidence of head trauma
- Known substance misuse or alcohol excess
- Inability to understand plain verbal or written English
- Severe mental health issues
- Receiving formal psychiatric treatment
- Currently held under the Mental Health Act
- If the subject's psychological health was deemed to be at risk from inclusion
- Imprisoned
- Contraindications to MRI
- non-compatible pacemakers
- surgical metalwork or foreign bodies
- severe claustrophobia
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2017
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03242395
Start Date
October 1 2014
End Date
April 1 2017
Last Update
August 8 2017
Active Locations (1)
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1
Chelsea and Westminster Hospital NHS Foundation Trust
London, United Kingdom, SW10 9NH