Status:
COMPLETED
Mental Ability Challenge Study in Adults With and Without HIV
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
HIV-1-infection
Aging, Premature
Eligibility:
All Genders
35+ years
Brief Summary
It is estimated that by 2016, nearly 50% of HIV-positive individuals in the US will be aged 50 or older, and up to 60% of those will experience some degree of cognitive impairment as they age. The pur...
Detailed Description
This study is intended to evaluate the involvement of the neuronal cholinergic receptor system in the accelerated cognitive aging profile seen in adults living with chronic HIV-1 infection. It is esti...
Eligibility Criteria
Inclusion
- 35 years of age or older;
- HIV-Positive (must be on ART's for at least 6 months, most recent viral load (within 6 months) \<50, CD4+ count \>200, must be diagnosed HIV-positive at least 5 years) or HIV-Negative, At-Risk Individuals
- Able and willing to give written informed consent
- Negative urine pregnancy test
- Adequate visual and auditory acuity to allow neuropsychological testing.
Exclusion
- Unmanaged HIV Infection, identified by no current medication regimen or the presence of one or more AIDS-defining conditions
- Fagerstrom cigarettes per day (CPD) score of '2' indicating heavy use of nicotine
- An ART regimen including a Protease Inhibitor Medication
- A documented history of cardiac disease or abnormal ECG at Screening
- Current alcohol or substance abuse, particularly intravenously
- Current use of psychoactive medications (antipsychotics, benzodiazepines, etc.)
- Current Axis I or Axis II psychiatric disorder
- History of myocardial infarction in the past year or unstable or severe cardiovascular disease
Key Trial Info
Start Date :
December 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2018
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03244488
Start Date
December 1 2015
End Date
December 1 2018
Last Update
February 25 2019
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212