Status:
COMPLETED
The Role of GLP-1 Receptor Signalling in the Glucose-lowering Effect of Metformin in Patients With T2D
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Collaborating Sponsors:
University of Copenhagen
Conditions:
Glucose Metabolism Disorders
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Delineation of the role of glucagon-like peptide-1 receptor signalling in the glucose-lowering effect of metformin during meal ingestion in patients with type 2 diabetes.
Detailed Description
Aim: To evaluate the contribution of metformin-induced GLP-1 secretion on the glucose-lowering effect of metformin in patients with type 2 diabetes treated with metformin for 14 days. Furthermore, the...
Eligibility Criteria
Inclusion
- Type 2 diabetes for at least three months (diagnosed according to the criteria of the World Health Organization (WHO)), with a HbA1c \<58 mmol/mol.
- Caucasian ethnicity
- Lifestyle intervention and/or metformin monotherapy
- Normal haemoglobin
- Age \>18 years
- BMI \>23 kg/m2 and \<35 kg/m2
- Informed and written consent
Exclusion
- Liver disease
- Gastrointestinal disease, previous intestinal resection, cholecystectomy or any major intra-abdominal surgery
- Hypo- or hyperphosphataemia
- Reduced kidney function or nephropathy
- Treatment with medicine that cannot be paused for 12 hours
- Intake of antibiotics two months prior to study
- Hypo- or hypercalcaemia
- Hypo- and hyperthyroidism
- Treatment with oral anticoagulants
- Active or recent malignant disease
- Any treatment or condition requiring acute or sub-acute medical or surgical intervention
- Lack of effective birth control in premenopausal women
- Positive pregnancy test on study days in premenopausal women
- Pregnancy
- Women who are breastfeeding
- Any condition considered incompatible with participation by the investigators
- If the subjects receive any antibiotic treatment while included in the study they will be excluded
Key Trial Info
Start Date :
July 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 10 2017
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT03246451
Start Date
July 1 2017
End Date
December 10 2017
Last Update
July 9 2018
Active Locations (1)
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1
Center for Diabetes Research
Gentofte Municipality, Copenhagen, Denmark, 2900