Status:
COMPLETED
fMRI of Hypothalamic Responses to Glucose, Fructose, Sucrose and Sucralose
Lead Sponsor:
Unilever R&D
Collaborating Sponsors:
Leiden University Medical Center
Conditions:
Healthy
Eligibility:
MALE
18-25 years
Phase:
NA
Brief Summary
The study will consist of five occasions with one week in between. BOLD signal intensity of the hypothalamus will be measured using fMRI. Measurements will be done before and after drinking 300 ml pla...
Detailed Description
The hypothalamus is known to be important for control of feeding behaviour as well as the regulation of temperature. Functional magnetic resonance imaging (fMRI) is a non-invasive method, which detect...
Eligibility Criteria
Inclusion
- Signed informed consent
- Age between 18 and 25 years
- BMI between 20 and 24 kg/m2
- Length between 170 and 190 centimetres
Exclusion
- Diabetes or history of other disturbances of glucose metabolism (eg impaired glucose tolerance, hypoglycaemia).
- Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain
- Any significant chronic disease
- Renal or hepatic disease
- Recent weight changes or attempts to lose weight (\> 3 kg weight gain or loss, within the last 3 months)
- Smoking (current or last 6 months)
- Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year
- Recent blood donation (within the last 2 months)
- Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year
- Contra-indication to MRI scanning:
- Claustrophobia
- Pacemakers and defibrillators
- Nerve stimulators
- Intracranial clips
- Intraorbital or intraocular metallic fragments
- Cochlear implants
- Ferromagnetic implants
Key Trial Info
Start Date :
February 22 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 22 2015
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03247114
Start Date
February 22 2015
End Date
May 22 2015
Last Update
August 11 2017
Active Locations (1)
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1
Leids Universitair Medisch Centrum
Leiden, South Holland, Netherlands