Status:
UNKNOWN
Memory Preservation of Hippocampal Avoidance Whole Brain Radiotherapy
Lead Sponsor:
Kaohsiung Medical University Chung-Ho Memorial Hospital
Conditions:
Brain Metastases
Neurocognitive Function
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
The study aimed to investigate the memory preservation and neurocognitive function protection of hippocampal avoidance whole brain radiotherapy (HA-WBRT) among people who speak Mandarin Chinese or Tai...
Detailed Description
Brain metastasis is very common, about 30% incidence rate for all patients with a diagnosis of cancer. The rising incidence of brain metastasis is most likely due to recent advances in systemic therap...
Eligibility Criteria
Inclusion
- Patients with brain metastases, the brain metastases are located 5mm outside the hippocampus
- Pathologically proven diagnosis of nonhematopoietic malignancy other than germ cell malignancy
- No psychologic disorders
- Radiation Therapy Oncology Group recursive partitioning analysis class I or II
- First or second language: Mandarin Chinese or Taiwanese
- Signed the inform consensus
Exclusion
- Less than 20 years old
- Leptomeningeal metastases or hydrocephalus
- Previous radiotherapy to head and neck region
- Creatinine \>1.5mg/dl
- More than 2 extracranial metastases
- Patients who cannot tolerate memory or neurocognitive function test or cannot complete QoL questionnaire
Key Trial Info
Start Date :
March 27 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03247127
Start Date
March 27 2017
End Date
December 31 2020
Last Update
August 28 2018
Active Locations (1)
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1
Fang, Pen-Tzu
Kaohsiung City, Taiwan, 80660