Status:
UNKNOWN
Lidocaine-Ketamine for Management of Chronic Pain
Lead Sponsor:
Hamilton Health Sciences Corporation
Conditions:
Chronic Pain Syndrome
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Chronic pain is defined as 'an unpleasant sensory and emotional experience associated with actual or potential tissues damage, or described in terms of such damage". It is estimated that 1 in 5 Canadi...
Eligibility Criteria
Inclusion
- Age 18-90
- Pain duration: \> 3 months
- Multifocal and/or non-dermatomal neuropathic pain per Pain Diagram
- Failed medical management with at least 2 neuromodulation agents (e.g., gabapentinoids, antidepressants)
- Neuropathic component (\>15 points on S-LANSS)
Exclusion
- Non-English speakers
- Refusal to sign informed consent
- Body weight \> 100 kg
- Allergies to ketamine and/or lidocaine
- Known contraindications to ketamine use which include poorly controlled systemic illnesses: arterial hypertension, hyperthyroidism, ischemic heart disease, heart failure, psychiatric comorbidity (e.g., history of psychosis, schizophrenia, dissociative state).
- Known contraindication to lidocaine use which include current symptomatic or clinically significant brady- or tachyarrhythmia, systolic blood pressure \<90 or \>180 mmHg.
- Scheduled interventions targeting neuropathic pain: epidural injections, peripheral nerve blocks, Bier block, radiofrequency of dorsal root ganglia and peripheral nerves, additional lidocaine or ketamine infusions
- Newly added analgesic or neuromodulating medications, or recently performed interventions including lidocaine infusions (in the previous 3 months), or previous lidocaine/ketamine infusion in the previous 360 days. -Acute intoxication or active illegal substance abuse (excluding marijuana)
Key Trial Info
Start Date :
September 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT03249025
Start Date
September 1 2017
End Date
September 1 2018
Last Update
August 15 2017
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