Status:
UNKNOWN
Individualised Weaning From Mechanical Ventilation in General ICU
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Collaborating Sponsors:
Aalborg University
Conditions:
Ventilatory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients residing in the intensive care unit typically receive mechanical ventilatory support. Selecting the appropriate level of mechanical ventilation is not trivial, and it has been shown that lung...
Detailed Description
All patients admitted to the ICU with mechanical ventilation are screened for inclusion. Patients receiving invasive mechanical ventilation (≥ 24 h) will be considered for inclusion in the study on a ...
Eligibility Criteria
Inclusion
- Patient is expected to be on invasive mechanical ventilation more 24 hours.
- Age \> 18 years
- Haemodynamically stable (with instability defined by the presence of two or more of the following criteria: acidosis pH \< 7.2, poor urine output \< 0.5ml/kg, use of vasopressors, e.g. noradrenline \> 25 μg/min).
- Patient consent or, in the case that the patient is unable, assent from the next of kin or treating physician following understanding and accept of oral and written information describing the study
Exclusion
- The absence of an arterial catheter for blood sampling at study start.
- Medical history of home mechanical ventilation which may lead to prolonged stay in the ICU, including long term oxygen therapy and non-invasive ventilation not associated with sleep apnoa.
- Clinical conditions requiring treatment with extracorporeal membrane oxygenation, i.e. an inspired oxygen of 100% for more than 24 hours.
- Head trauma or other conditions where intra-cranial pressure may be elevated and tight regulation of arterial CO2 level is paramount.
- Primary neurological patients (Glasgow coma score \<10, neurologic damage with limited prognosis, stroke hemiplegia).
- Severe heart failure, classified as grade 4 of the Association of Cardiology guidelines \[2\].
- End stage liver disease.
- Multiple medical ICU admissions, i.e. more than one admission.
- Corrective orthognathic surgery.
- Esophageal surgery.
- Morbidly obese patients defined as either BMI\>45, or 35\<BMI\<45 with APACHEII score on admission greater than 24.
- Pregnancy.
- Mechanical ventilation initiated for more for 24 hours in other centers
Key Trial Info
Start Date :
December 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2021
Estimated Enrollment :
274 Patients enrolled
Trial Details
Trial ID
NCT03249623
Start Date
December 11 2017
End Date
July 30 2021
Last Update
July 21 2020
Active Locations (1)
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1
The Magill Department of Anaesthesia, Chelsea and Westminster Hospital
London, United Kingdom, SW10 9NH