Status:
WITHDRAWN
Interhemispheric Interaction of Parieto-Motor Cortico-Cortical Plasticity
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18-55 years
Brief Summary
Background: The two hemispheres of the brain are connected. Changes in one hemisphere affect the other through this connection. Research has shown that training new skills in one hand improves the sa...
Detailed Description
Objective: The purpose of this study is to evaluate the effect of long-term potentiation (LTP)-like cortical plasticity induced by parieto-motor cortico-cortical paired associative stimulation (cc-PA...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Between the age of 18 and 55 years
- Right-handed
- English speaking
- Ability to give informed consent
- EXCLUSION CRITERIA:
- Illegal drugs use within the past 6 months based on history alone
- Abnormal findings on neurologic examination
- Have more than 7 alcoholic drinks a week in the case of a woman or 14 alcoholic drinks a week in the case of a man
- History of or current brain tumor, stroke, head trauma with loss of consciousness \>few seconds, epilepsy or seizures
- History of or current episode of major depression or any major psychiatric illness (axis I disorders)
- Current diagnosis of neurologic disorder
- Presence of pacemaker, intracardiac lines, implanted pumps or stimulators, or metal objects inside the eye or skull. Dental fillings and dental braces are allowed.
- Open scalp wounds or scalp infection
- Employees and/or staff of HMCS/NINDS
- Taking benzodiazepines at the time of the entire study or within 12 days prior to the study. NOTE: Medication will not be stopped or held for participation in this study.
- Taking, at the time of the entire study or within 2 weeks prior to the study, any medication that acts as a central nervous system stimulant or that is known to lower seizure threshold, including, imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, foscarnet, ganciclovir, ritonavir, amphetamines, ketamine, gamma-hydroxybutyrate (GHB), theophylline, mianserin, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, reboxetine, venlafaxine, duloxetine, bupropion, mirtazapine, fluphenazine, pimozide, haloperidol, olanzapine, quetiapine, aripiprazole, ziprasidone, risperidone, chloroquine, mefloquine, imipenem, penicillin, ampicillin, cephalosporins, metronidazole, isoniazid, levofloxacin, cyclosporine, chlorambucil, vincristine, methotrexate, cytosine arabinoside, BCNU, lithium, antihistamines, and sympathomimetics. NOTE: Medication will not be stopped or help for participation in this study.
- Being pregnant
- You may not be eligible to have MRI or TMS in this study if:
- You have metal in your body which would make having an MRI scan unsafe, such as pacemakers, stimulators, pumps, aneurysm clips, metallic prostheses, artificial heart valves, cochlear implants or shrapnel fragments, or if you were a welder or metal worker, since you may have small metal fragments in the eye.
- You are uncomfortable in small closed spaces (you have claustrophobia) so that you would feel uncomfortable in the MRI machine.
- You are not able to lie comfortably on your back for up to 1 hour
- You have a hearing loss reported in the history or detected in the routine physical examination
Exclusion
Key Trial Info
Start Date :
August 11 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 9 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03253731
Start Date
August 11 2017
End Date
November 9 2018
Last Update
November 20 2018
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