Status:
COMPLETED
Identification and Evaluation of Biomarkers of Resistance to Neoadjuvant Chemotherapy (IDEA SEIN)
Lead Sponsor:
Institut du Cancer de Montpellier - Val d'Aurelle
Conditions:
Breast Cancer
Eligibility:
FEMALE
18+ years
Phase:
NA
Brief Summary
Biomarkers of resistance to neoadjuvant chemotherapy in locally advanced breast cancer
Detailed Description
Identification and evaluation of biomarkers of resistance to neoadjuvant chemotherapy and establishment of preclinical models of resistance in locally advanced breast cancer
Eligibility Criteria
Inclusion
- proven invasive breast adenocarcinoma (cytology and / or biopsy).
- locally advanced stage (tumor size greater than 2 cm).
- neoadjuvant chemotherapy indication validated RCP
- Patient eligible for neoadjuvant chemotherapy.
- Performance Index according to WHO or less 1.
- Patient aged 18 years and older.
- Being affiliated to a social security scheme or an equivalent scheme of social protection
- Obtaining signed informed consent, and that before any specific prequalification testing.
Exclusion
- presence of metastatic disease at diagnosis.
- Breast Cancer inflammatory.
- rare histologic subtypes (non ductal lobular and not).
- Other cancer (except basal cell skin carcinoma and cancer of the cervix in situ adequately treated and curative) treated in the previous 5 years.
- Patient pregnant or nursing or of childbearing age without effective contraception.
- Breast cancer in men.
- legal incapacity or limited legal capacity. medical or psychological conditions allowing the subject to complete the study or to sign the consent (art. L.1121-6, L.1121-7, L.1211-8, L1211-9).
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2016
Estimated Enrollment :
164 Patients enrolled
Trial Details
Trial ID
NCT03255486
Start Date
July 1 2013
End Date
December 1 2016
Last Update
August 21 2017
Active Locations (1)
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1
Institut régional du Cancer de Montpellier
Montpellier, France, 34298