Status:
COMPLETED
Pimo Study: Extracellular Vesicle-based Liquid Biopsy to Detect Hypoxia in Tumours
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Conditions:
Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to test the potential of a relatively simple serum assay that aims to identify patient subpopulations whose curative radiotherapy outcome is likely to be compromised by ra...
Detailed Description
Aim: To analyse tiny cancer cell fragments called extracellular vesicles isolated from blood samples for their ability to identify patients with tumours that are relatively oxygen-starved and expected...
Eligibility Criteria
Inclusion
- Patients i) Age ≥18 years ii) Biopsy-proven invasive carcinomas of head and neck, lung, bladder, uterine cervix or breast iii) Bulky (≥4 cm or ≥ 30 cc) primary/locally recurrent tumour or regional node masses iv) No clinical evidence of distant metastases unless oligometastases (ie distant relapse in only a limited number of regions for which local ablative therapy could be curative) v) Patient due for surgery, radiotherapy, systemic therapy or no anti-cancer treatment vi) Written informed consent
- Healthy volunteers i) Age ≥18 years ii) Written informed consent
Exclusion
- Patients i) Inadequate cognitive ability to undertake the appropriate informed consent procedure
- Healthy volunteers i) Past history of cancer, apart from non-melanomatous skin cancer or in situ carcinoma uterine cervix
Key Trial Info
Start Date :
November 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 12 2019
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03262311
Start Date
November 10 2017
End Date
September 12 2019
Last Update
December 23 2019
Active Locations (1)
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1
The Royal Marsden NHS Foundation Trust
Sutton, Surrey, United Kingdom, SM2 5PT