Status:
UNKNOWN
Effects of Progressive Negative Energy Balance on Glucose Tolerance, Insulin Sensitivity, and Beta-cell Function
Lead Sponsor:
Singapore Institute of Food and Biotechnology Innovation
Conditions:
Insulin Sensitivity
Glucose Intolerance
Eligibility:
All Genders
21-65 years
Phase:
NA
Brief Summary
Type 2 diabetes results from a combination of peripheral insulin resistance and beta-cell dysfunction, and manifests as fasting and postprandial hyperglycemia. In Singapore, despite the relatively low...
Detailed Description
Metabolic dysfunction, obesity, and type 2 diabetes The incidence of overweight and obesity has been increasing during the past 2-3 decades in Singapore, and is expected to rise further in the future....
Eligibility Criteria
Inclusion
- Healthy males and females
- Age between 21-65 years
- BMI from ≥18 to \<30 kg/m2 (BMI is equal to body weight in kilograms divided by height in metres squared)
Exclusion
- Persons with metabolic diseases that require use of medications (e.g. diabetes, heart disease, hypertension, etc.)
- Persons using tobacco products (smokes daily or occasionally)
- Persons who regularly consume alcohol (≥1 drink/day)
- Women on oral contraceptives or hormone replacement therapy
- Pregnant or breastfeeding women
- Persons who have had recent weight loss or gain (≥5% over the past 6 months)
- Persons with contraindication to calorie restriction (e.g. anemia) or exercise (e.g. asthma)
Key Trial Info
Start Date :
April 4 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT03264001
Start Date
April 4 2017
End Date
December 31 2018
Last Update
March 13 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Clinical Nutrition Research Centre
Singapore, Singapore, 117609