Status:
RECRUITING
Impact of Epileptic Discharge on the Structural Connectivity of the Developing Brain
Lead Sponsor:
Fondation Ophtalmologique Adolphe de Rothschild
Conditions:
Epilepsies, Focal
Pediatrics
Eligibility:
All Genders
18-16 years
Brief Summary
Focal epilepsy is associated with widespread alterations in structural brain connectivity, often present at the disease onset and related to learning disabilities. Whether ongoing seizure activity con...
Detailed Description
Drug-resistant focal epilepsy is a debilitating disease as it is often accompanied by learning disabilities and behavioral disorders, that can be present at the disease onset and have ample repercussi...
Eligibility Criteria
Inclusion
- \- Drug resistant focal epilepsy
- Inclusion Criteria for control patients:
- \- without drug resistant focal epilepsy
Exclusion
- Severe mental retardation (IQ \< 50)
- Lack of French-language skills
- Contraindications to MRI
- Bi-hemispherical epilepsy or affecting multiple lobes
- Exclusion Criteria for control patients:
- Severe mental retardation (IQ \< 50)
- Lack of French-language skills
- Contraindications to MRI
- Congenital pathology altering cerebral connectivity
- Parenchymal brain lesions
- Unilateral or bilateral blindness
- Unilateral or bilateral deafness
- Autistic disorders
Key Trial Info
Start Date :
December 19 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
82 Patients enrolled
Trial Details
Trial ID
NCT03268824
Start Date
December 19 2017
End Date
July 1 2026
Last Update
January 5 2026
Active Locations (1)
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1
Fondation Ophtalmologique A. de Rothschild
Paris, France