Status:
COMPLETED
Improving Cognition Via Exercise in Schizophrenia
Lead Sponsor:
Icahn School of Medicine at Mount Sinai
Collaborating Sponsors:
University of North Carolina, Chapel Hill
Stanford University
Conditions:
Schizophrenia and Related Disorders
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
People with schizophrenia display a broad range of cognitive impairments that have been identified as major determinants of poor functioning and disability. Also, people with schizophrenia are at incr...
Detailed Description
The goal of the proposed study is to examine the impact of remote exercise training on cognitive functioning in people with schizophrenia. People with schizophrenia display a broad range of cognitive ...
Eligibility Criteria
Inclusion
- A DSM-V diagnosis of schizophrenia, schizoaffective, or schizophreniform disorder.
- Age 18-55 years.
- Taking antipsychotic medication for at least 8 weeks and on current doses for 4 weeks, and/or injectable depot antipsychotics with no change in the last 3 months.
- Capacity to understand all the potential risks and benefits of the study.
- Medically cleared by a physician to take part in VO2max tests and aerobic exercise training or stretching-and-toning exercise training.
Exclusion
- A DSM-V diagnosis of alcohol/substance abuse (except nicotine) within the last month or a diagnosis of alcohol/substance dependence (except nicotine) within the last 6 months
- Initiation of anti-depressants, mood stabilizers, or other medications known to impact cognition in previous 4 weeks or any change in doses during this period.
- History of seizures/head trauma with loss of consciousness (\>10 minutes) resulting in cognitive sequelae.
- Significant clinical abnormalities in physical examination, lab assessments, or ECG.
- Neurological/medical conditions that could interfere with study participation (e.g., unstable cardiac disease, stuttering).
- Body Mass Index (BMI) ≥ 40.
- Untreated hyper- or hypothyroidism.
- Being pregnant or nursing.
- Serious homicidal/suicidal risk (past 6 months).
- "Moderate" or more severe conceptual disorganization (PANSS≥4).
- Poor English reading ability (WTAR\<7).
- Participation in a study with cognitive assessment in the past 3 months.
- Serious homicidal risk (past 6 months)
Key Trial Info
Start Date :
April 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2023
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT03270098
Start Date
April 26 2018
End Date
January 31 2023
Last Update
April 14 2023
Active Locations (4)
Enter a location and click search to find clinical trials sorted by distance.
1
Stanford University
Stanford, California, United States, 94305
2
Augusta University
Augusta, Georgia, United States, 30912
3
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
4
University of North Carolina
Chapel Hill, North Carolina, United States, 27599