Status:
ACTIVE_NOT_RECRUITING
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
Lead Sponsor:
Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Collaborating Sponsors:
Rotman Research Institute at Baycrest
Canadian Institutes of Health Research (CIHR)
Conditions:
Subjective Cognitive Decline
Eligibility:
All Genders
60-85 years
Phase:
NA
Brief Summary
The team "Cognitive intervention, cognitive reserve and brain plasticity", Team 10, is part of the Canadian Consortium on Neurodegeneration in Aging (CCNA). The team's aim is to develop and test a mul...
Detailed Description
In the absence of a cure for Alzheimer's disease (AD), there is paramount interest for non-pharmacological cognitive interventions that are designed to restore, increase, or optimize capacities and ad...
Eligibility Criteria
Inclusion
- Possess sufficient visual and auditory acuity to undergo neuropsychological tests and to do the intervention.
- Commit for the whole intervention + 2 follow-up sessions 2 years from pre-test.
- Have an internet connection at home.
- Answer 'Yes' to both following questions: "Do you feel like your memory is becoming worse?" "Does this worry you?"
- Have a delayed recall score above the education-adjusted cut-offs (≥9 for 16+ years of education; ≥5 for 8-15 years of education; ≥3 for 0-7 years of education) at the Logical Memory test (Wechsler Memory Scale, maximum score 25).
- Have a Montreal Cognitive Assessment (MoCA) total score of 20 and above (≥20/30).
- Have a delayed recall score at the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Word List task above 4 (\>4).
- Have a global Clinical Dementia Rating score (CDR) equal to 0 or 0.5 (=0 to 0.5).
Exclusion
- The presence of disease or injury of the central nervous system, such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, subdural hematoma (past or current), subarachnoid haemorrhage (past or current), primary cerebral tumour or cerebral metastases, epilepsy (current), dementia or another neurodegenerative disease, and other rarer brain illnesses.
- Symptomatic stroke within the previous year.
- History of intracranial surgery.
- Major surgery within last 2 months.
- Serious comorbid condition that, in the opinion of the study investigator, is likely to result in death within a year.
- Major depression or anxiety.
- Schizophrenia or other major psychiatric disorder.
- Ongoing alcohol or drug abuse that in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures.
- Subject does not have a study partner who can provide corroborative information.
- Individuals where English (Toronto) or French (Montreal) is not sufficiently proficient for clinical assessment and neuropsychological testing.
- Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure.
- Plans on moving outside the province within the next 2 years.
- Musicianship: more than 5 years of formal music training in total life or more than 10 years of choir experience.
- Fluency in Spanish: has learned Spanish after secondary school for more than 5 years, speaks Spanish at home, has ever lived in a Hispanic country.
Key Trial Info
Start Date :
September 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2025
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT03271190
Start Date
September 15 2017
End Date
March 31 2025
Last Update
August 28 2024
Active Locations (2)
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1
Rotman Research Institute, Baycrest
Toronto, Ontario, Canada, M6A 2E1
2
CRIUGM
Montreal, Quebec, Canada, h3w 1w4