Status:
COMPLETED
Exercise and Brain Vascular Function
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Physical Exercise
Cerebrovascular Function
Eligibility:
MALE
60-70 years
Phase:
NA
Brief Summary
Cognitive performance is negatively related to an impaired glucose metabolism, possibly due to impairments in brain vascular function. Supported by the statement from the American Heart and Stroke Ass...
Eligibility Criteria
Inclusion
- Aged between 60-70 years
- Men
- BMI between 25-35 kg/m2 (overweight and slightly obese)
- Sedentary (not moderately active for 3 times or more per week)
- Fasting plasma glucose \< 7.0 mmol/L
- Fasting serum total cholesterol \< 8.0 mmol/L
- Fasting serum triacylglycerol \< 4.5 mmol/L
- Systolic blood pressure \< 160 mmHg and diastolic blood pressure \< 100 mmHg
- Stable body weight (weight gain or loss \< 3 kg in the past three months)
- Willingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
- No difficult venipuncture as evidenced during the screening visit
Exclusion
- Women
- Current smoker, or smoking cessation \< 12 months
- Diabetic patients
- Familial hypercholesterolemia
- Abuse of drugs
- More than 3 alcoholic consumptions per day
- Use of dietary supplements known to interfere with the main study outcomes as judged by the principal investigators
- Use medication to treat blood pressure, lipid or glucose metabolism
- Use of an investigational product within another biomedical intervention trial within the previous 1-month
- Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis
- Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident
- Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT03272061
Start Date
December 1 2017
End Date
December 31 2018
Last Update
January 16 2019
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Netherlands