Status:
UNKNOWN
Comparing Effects and Neural Mechanisms of Tai Chi and Light-to-Moderate Intensity Aerobic Exercises
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Physical Activity
Eligibility:
All Genders
45-80 years
Phase:
NA
Brief Summary
In this three-year project, investigators will target on sedentary middle-aged and older adults with cardiovascular risks, prescribe 24-week Tai Chi or aerobic exercises and examine: 1. Whether both ...
Detailed Description
Leukoaraiosis prevails in middle-aged and older adults with cardiovascular risks. People with more severe leukoaraiosis would have greater risks for stroke, dementia, and disability. Tai Chi and aerob...
Eligibility Criteria
Inclusion
- Age between 45 and 80 years old
- Literacy
- With cardiovascular risks, defined as having hypertension (defined as resting systolic BP≧140 mmHg or resting diastolic BP≧90 mmHg, or receiving antihypertensive medication), diabetes mellitus (defined as taking oral antidiabetics or insulin or fasting plasma glucose being ≥100 mg/dL), dyslipidemia (defined as receiving lipid-lowering medication and diet therapy or total cholesterol \> 200 mg/dL or triglyceride \> 150 mg/dL (Lan et al., 2008)), or a combination of two or three of these risks
- Being physically inactive (defined as being engaged in physical activities for less than a total of 90 minutes per week) in recent one year
- Have no prior experiences with Tai Chi, yoga, chi gung, or other meditative forms of exercises
- No expectation of the need of changing medication in the following 8 months from the physicians
Exclusion
- Having any contraindications for fMRI (e.g., claustrophobia and indwelling metals or implanted devices)
- Serious or uncontrolled cardiac or metabolic conditions (e.g., unstable angina, serious cardiac arrhythmias, heart failure, hypertrophic cardiomyopathy, severe aortic or carotid stenosis, pulmonary embolus or infarction, resting systolic BP ≥ 180 mmHg, resting diastolic BP ≥ 110 mmHg, fasting plasma glucose ≥ 300 mg/dL)
- Severe renal failure
- Symptoms or history of neurological diseases, including transient ischemic attack
- Severe musculoskeletal disorders which would affect their mobility
- Dementia or inability to follow instructions
- Psychiatric disorder
- Having contraindications for doing exercises (e.g., resting systolic BP ≥ 180 mmHg, resting diastolic BP ≥ 110 mmHg, fasting plasma glucose ≥ 300 mg/dL, hypoglycemia (plasma glucose ≤ 70 mg/dL) after exercises, and postural hypotension (BP drop ≥ 20 mmHg when changing postures)
Key Trial Info
Start Date :
August 31 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2020
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03275038
Start Date
August 31 2017
End Date
July 31 2020
Last Update
September 7 2017
Active Locations (1)
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1
National Taiwan University Collage of Public Health
Taipei, Zhongzheng, Taiwan, 100