Status:
UNKNOWN
Biorhythms in Metabolic Tissues
Lead Sponsor:
Uppsala University
Collaborating Sponsors:
The Swedish Research Council
Conditions:
Sleep Deprivation
Metabolic Disturbance
Eligibility:
All Genders
18-32 years
Phase:
NA
Brief Summary
Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are appr...
Eligibility Criteria
Inclusion
- Age 18-33 yr
- Healthy (self-reported) and not on medication
- BMI 18-28 kg/m2 (and waist circumference \<102 cm), and weight stable (±5% body weight in past 6 months)
- Non-smoker and non-nicotine user
- Regular sleep-wake pattern, with sleep duration of 7-9.25 hrs per night
- Sedentary to moderately active with regular exercise habits the last 2 months
- Regular daily meal pattern with 3 main meals
Exclusion
- Major or chronic illness, e.g. diabetes, renal disease or inflammatory bowel disease
- Current or history of endocrine or metabolic disorders
- Psychiatric or neurological disorders (e.g. bipolar disorder, epilepsy)
- Frequent gastrointestinal symptoms
- Chronic medication
- Any sleep disorder (e.g. irregular bedtimes, symptoms of insomnia)
- Any issues with or allergies against the provided food items or utilized anesthesia
- Shift work in the preceding three months or for a long duration
- Time travel over two time zones in the preceding month
- Too much weight gain or weight loss in the preceding 6 months
- Pregnancy
Key Trial Info
Start Date :
August 31 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03276442
Start Date
August 31 2017
End Date
December 31 2019
Last Update
October 12 2017
Active Locations (1)
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1
Department of Neuroscience, Uppsala University
Uppsala, Sweden, 75324