Status:
UNKNOWN
Early Outcome in Unstable Angina Patients With Low EF After CABG
Lead Sponsor:
Assiut University
Conditions:
CABG in Low EF
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Coronary artery bypass grafting (CABG) among patients with reduced myocardial function remains a surgical challenge despite improvement in surgical technique, myocardial protection and postoperative c...
Detailed Description
Current treatment options for Chronic Unstable Angina patients with low Ejection Fraction include intensive medical therapy, surgical revascularization, ventricular remodeling, and heart transplantati...
Eligibility Criteria
Inclusion
- Angiographic indication for revascularization based upon symptoms of angina and/or objective evidence of myocardial ischemia.
- Preoperative EF ≤ 40 %.
- Preoperative myocardial viability (by cardiac MRI).
- Willing and able to provide written informed consent and comply with study requirements.
- Patient is willing to comply with all follow-up visits.
Exclusion
- Severe congestive heart failure (class III or IV according to NYHA, or pulmonary edema, cardiogenic shock) at the time of enrollment.
- Prior surgery with the opening of pericardium.
- Evidence of non-viable (scarred) myocardium.
- Prior stroke (within 6 months)or more than 6 months if there are substantial neurological defects.
- Acute ST-elevation MI within 72 hours prior to enrollment requiring revascularization.
- Planned simultaneous surgical procedure unrelated to coronary revascularization (e.g. valve repair/replacement, aneurysmectomy, carotid endarterectomy or carotid stenting).
- Significant leukopenia, neutropenia, thrombocytopenia, anemia, or known bleeding diathesis.
- Intolerance or contraindication to aspirin or both clopidogrel and ticlopidine.
- Extra-cardiac illness that is expected to limit survival to less than 5 years e.g. oxygen-dependent chronic obstructive pulmonary disease, active hepatitis or significant hepatic failure, severe renal disease.
- EF ≤ 20 %.
Key Trial Info
Start Date :
September 4 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03276624
Start Date
September 4 2017
End Date
March 1 2019
Last Update
September 8 2017
Active Locations (1)
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1
Assiut University hospitals
Asyut, Egypt, 71111