Status:
TERMINATED
Concurrent Training in Type 2 Diabetes
Lead Sponsor:
University of Birmingham
Collaborating Sponsors:
Loughborough University
Metabolic Fitness Association, Italy
Conditions:
Type 2 Diabetes Mellitus
Eligibility:
MALE
40-65 years
Phase:
NA
Brief Summary
It is recommended that individuals perform a combination of resistance exercise (RE) and endurance exercise. Lack of time is often cited as a reason for being unable to meet current exercise guideline...
Detailed Description
Data analysis will be performed using IBM SPSS statistical software (IBM Corp., Armonk, New York, USA). All data will be checked for normality and appropriate log transformations applied prior to anal...
Eligibility Criteria
Inclusion
- Male sex
- White British/European
- Aged between 40 and 65 years at the time of screening
- Have a body mass index (BMI; body weight/height in m2) between 27 and 40 kg/m2
- Sedentary/untrained for at least 1 year (based on physical activity self-reports of fewer than two sessions of structured exercise per week last \<30 min)
- T2DM (American Diabetes Association 2014) for more than 1 year
- Central obesity (defined as waist circumference ≥94 cm for males)
Exclusion
- Currently involved in research or have recently (\<6 months) been involved in any research prior to recruitment
- Any condition limiting or contraindicating physical activity; including diabetic peripheral neuropathy, and coronary or peripheral artery disease
- Previous myocardial infarction, previous or current angina, shortness of breath, or other symptoms suggestive of heart failure
- Insulin medication
- HbA1c more than 75 mmol/mol (9%)
- Uncontrollable hypertension: systolic blood pressure ≥160 mmHg and diastolic blood pressure ≥100 mmHg
- Not weight stable for the last three months
- Smokers (within the last 12 months)
- Anticoagulant medication, such as warfarin or newer anticoagulant drugs. If participants are on aspirin medication, this would need to be stopped for 3 days prior to and during the day of any biopsy visit unless contraindicated (in which case participants would be excluded).
Key Trial Info
Start Date :
December 6 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 12 2018
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03278704
Start Date
December 6 2017
End Date
July 12 2018
Last Update
July 17 2018
Active Locations (1)
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1
School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham
Birmingham, United Kingdom, B15 2TT