Status:
COMPLETED
F 18 T807 PET (Positron Emission Tomograph )Scan for HIV Infected & Uninfected
Lead Sponsor:
Tammie L. S. Benzinger, MD, PhD
Conditions:
Alzheimer Disease
HIV
Eligibility:
All Genders
40+ years
Brief Summary
This project will collect quantitative pilot data that will allow the characterization of uptake and binding of 18F-AV-1451 (also known as F 18 T807, also known as T807, also known as 7-(6-fluoropyrid...
Detailed Description
This protocol will demonstrate the presence of tau fibrils in older HIV+ patients with HIV associated neurocognitive disorders (HAND) compared to cognitively normal HIV+ individuals and HIV- controls....
Eligibility Criteria
Inclusion
- Male or female participants, ≥ 40 years of age.
- Testing for HIV status. If positive will be included in the HIV+ group and if negative will be included in the HIV- group.
- Females without documented history of menopause or hysterectomy will undergo a urine pregnancy test 24 hours prior to F 18 T807 drug administration.
Exclusion
- Has any condition that, in the Investigator's opinion, could increase risk to the participant, limit the participant's ability to tolerate the experimental procedures, or interfere with the collection/analysis of the data (for example, participants with severe chronic back pain might not be able to lie still during the scanning procedures).
- Is deemed likely unable to perform the imaging procedures for any reason.
- Has a high risk for Torsades de Pointes or is taking medications known to prolong QT interval.
- Has hypersensitivity to F 18 T807 or any of its excipients.
- Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to lie still for long periods) that make it unsafe for the individual to participate.
- Severe claustrophobia.
- Currently pregnant or breast-feeding.
Key Trial Info
Start Date :
May 3 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 23 2018
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03279523
Start Date
May 3 2016
End Date
May 23 2018
Last Update
September 22 2020
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110