Status:
UNKNOWN
Influence of EPICardial Adipose Tissue in HEART Diseases: EPICHEART Study
Lead Sponsor:
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Collaborating Sponsors:
Universidade do Porto
Conditions:
Coronary Artery Disease
Coronary Arteriosclerosis
Eligibility:
All Genders
18+ years
Brief Summary
This translational study was designed to explore the association of the quantity and quality of epicardial adipose tissue (EAT) with coronary artery disease (CAD), left atrial remodeling and postopera...
Detailed Description
Background: EAT has emerged as a new independent, and, potentially, modifiable cardiovascular risk factor for CAD. EAT volume assessed by computed tomography (CT) was independently associated with the...
Eligibility Criteria
Inclusion
- symptomatic severe aortic stenosis patients (defined as aortic valve area of \< 1 cm2 or 0.6 cm2/m2 by transthoracic echocardiography) referred to aortic valve replacement.
Exclusion
- diagnosis of acute coronary syndrome in the last 3 months.
- prior history of persistent or permanent atrial or flutter fibrillation.
- coexisting moderate to severe aortic valve regurgitation or moderate to severe mitral valve disease, bicuspid aortic valve.
- left ventricular dilatation \[end-diastolic volume index \>75 mL/m²\].
- left ventricular ejection fraction \<55%.
- chronic renal failure stage 3 to 5 defined as glomerular filtration rate GFR estimated by Cockcroft-Gault formula adjusted for body surface area \< 30 mL/min/1.73m².
- moderate to severe chronic obstructive pulmonary disease defined as forced expiratory volume in one second \<50% according to the 2011 Global Initiative for Chronic Obstructive Pulmonary Disease guidelines.
- active malignancy (i.e. With no evidence of recurrence and no longer receiving active treatment).
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 25 2018
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT03280433
Start Date
September 1 2014
End Date
November 25 2018
Last Update
September 14 2017
Active Locations (2)
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1
Centro Hospitalar de Vila Nova de Gaia/Espinho
Vila Nova de Gaia, Porto District, Portugal, 4430-502
2
Faculty of Medicine of Porto
Porto, Portugal, 4200-319