Status:
COMPLETED
Feasibility of High Intensity Interval Training in Knee Osteoarthritis
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
National Institutes of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Knee Osteoarthritis
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
The focus of this pilot study is to evaluate the feasibility of utilizing an evidenced-based high intensity interval training program (HIIT) to improve physical function in patients with knee osteoart...
Detailed Description
All participants will be assigned to the single-arm of the study in which all participants will receive 12 weeks of HIIT, delivered twice per week. The primary outcome will examine the feasibility and...
Eligibility Criteria
Inclusion
- between the ages of 40 and 75 years old
- body mass index of 18.5-50 kg/m²
- exhibits symptomatic knee OA, defined as a diagnosis of knee OA, as identified from University of North Carolina electronic medical records, and current knee symptoms in at least one knee, having a minimum score of 6 out of 20 on the Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) pain subscale.
Exclusion
- individuals diagnosed with a cardiovascular condition restricting exercise
- individuals currently meeting Department of Health and Human Services Guidelines for physical activity (≥ 150 minutes per week
- individuals currently doing HIIT
- individuals currently participating in physical therapy for knee OA
- individuals currently participating in another OA intervention study
- received a corticosteroid or hyaluronic acid intra-articular injection in the knee during the previous 3 weeks or scheduled for during the intervention
- diagnosis of gout in the knee
- diagnosis of rheumatoid arthritis
- diagnosis of fibromyalgia
- other systemic rheumatic disease
- severe dementia or other memory loss
- active diagnosis of psychosis or uncontrolled substance abuse disorder
- hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 3 months
- total joint replacement knee surgery, other knee surgery, meniscus tear, or anterior cruciate ligament (ACL) tear in the past 6 months
- on a waiting list for total joint replacement
- severely impaired hearing or speech
- pregnant or planning to become pregnant while enrolled in the study
- inability to speak English
- serious or terminal illness as indicated by referral to hospice or palliative care
- nursing home residence
- inability to ride a stationary bike
- any other health problems that would prohibit safe participation in the study
- EKG results EKG suggesting the individual would not be able to safely participate in this study
Key Trial Info
Start Date :
November 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 9 2018
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT03281668
Start Date
November 1 2017
End Date
November 9 2018
Last Update
November 22 2019
Active Locations (1)
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1
University of North Carolina
Chapel Hill, North Carolina, United States, 27599