Status:
UNKNOWN
Opioid-Induced Swallowing Dysfunction - The Impact of Bolus Volume
Lead Sponsor:
Region Örebro County
Conditions:
Pharyngeal Dysfunction
Pharyngeal Swallowing
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of the study is to evaluate the impact of different bolus volumes and viscosity on remifentanil-induced swallowing dysfunction in healthy volunteers.Hence, whether swallowing tasks can be ...
Detailed Description
Monitored anesthesia care (MAC) is commonly applied in modern perioperative care and means that minor surgical procedures are accomplished in awake patients using local anesthesia and light sedation. ...
Eligibility Criteria
Inclusion
- ≥ 18 - ≤ 40 year old healthy volunteers from both sexes.
- Have signed and dated Informed Consent.
- Willing and able to comply with the protocol for the duration of the trial.
Exclusion
- Anamnesis of pharyngoesophageal dysfunction.
- Known or history of gastrointestinal, severe cardiac, pulmonary or neurological disease
- Ongoing medication that may affect upper gastrointestinal tract, larynx or lower airway.
- Allergies to or history of reaction to remifentanil, fentanyl analogues or dexmedetomidine.
- Pregnancy or breast feeding
- BMI \> 30
- Smoking
- Previous participation in a medicinal clinical trial during the last year where an opioid has been used or have during the last 30 days participated in any other medicinal clinical trial or in a trial where follow-up is not completed.
Key Trial Info
Start Date :
November 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03283020
Start Date
November 11 2017
End Date
April 1 2018
Last Update
December 12 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Anaesthesiology and Intensive Care, Örebro University Hospital
Örebro, Sweden, 70185