Status:
COMPLETED
Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.
Lead Sponsor:
Ghulam Nabi
Conditions:
Reproductive Physiological Phenomena
Eligibility:
MALE
Phase:
PHASE3
Brief Summary
The specific objective of this study was to investigate the sensitivity of Kisspeptin receptor 1 (KISS1R) by determining the responsiveness of GnRH neuron to kisspeptin administration across the puber...
Detailed Description
No studies in humans are available regarding KISS1R signalling that, whether expression of the KISS1 or KISS1R sensitivity increases during the pubertal transition in boys. Kisspeptin regulates HPG (h...
Eligibility Criteria
Inclusion
- Boys were classified into 5 different Tanner stages (I-V) according to the criteria of Feingold D. In Atlas of physical diagnosis. Pediatric endocrinology. 2nd ed. Philadelphia. WB Saunders; 1992, pp. 16-19. For comparison, adult men were also recruited.
Exclusion
- Individuals with chronic illness or disorder, i.e. hepatic and renal complications, epilepsy, pneumonia, asthma, orchitis, hernia, cryptorchidism, mental retardation, etc. were excluded from this study
Key Trial Info
Start Date :
June 26 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 5 2015
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03286517
Start Date
June 26 2014
End Date
March 5 2015
Last Update
September 18 2017
Active Locations (1)
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1
Quaid-i-Azam University
Islamabad, Pakistan, 45320