Status:
COMPLETED
Protocolized Post-Extubation Respiratory Support Study
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Mechanical Ventilation Complication
Acute Respiratory Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Invasive mechanical ventilation is common in the medical intensive care unit, and the period of time following extubation remains high risk as 11 to 15% of patients require reintubation after their fi...
Detailed Description
PROPER is a prospective, pragmatic, cluster-randomized, multiple-crossover trial comparing a respiratory therapist driven protocol for post-extubation respiratory support to usual care. The primary ou...
Eligibility Criteria
Inclusion
- Patient is located in a participating unit
- Patient undergoing extubation from mechanical ventilation
- Patient has been receiving mechanical ventilation for at least 12 hours
- Age ≥ 18 years old
Exclusion
- Patient is receiving ventilation via a tracheostomy
- Patient is being extubated to comfort measures or has "Do Not Reintubate" order in place at the time of extubation
- Patient has required reintubation after a prior attempt at extubation during this hospitalization
- Unplanned or self-extubation, where immediate reintubation is deemed necessary by the clinical team
Key Trial Info
Start Date :
October 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 28 2019
Estimated Enrollment :
751 Patients enrolled
Trial Details
Trial ID
NCT03288311
Start Date
October 1 2017
End Date
April 28 2019
Last Update
December 29 2023
Active Locations (1)
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1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37212