Status:
COMPLETED
Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions:
Cardiac Surgery
Dexmedetomidine
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
A retrospective study showed that intraoperative dexmedetomidine administration was associated with decreased risk of 1-year mortality after cardiac surgery. In a previous randomized controlled trial,...
Detailed Description
Dexmedetomidine is a highly selective alpha 2-adrenergic receptor agonist that provides anti-anxiety, sedation, and modest analgesic effects. In a retrospective cohort study of patients undergoing car...
Eligibility Criteria
Inclusion
- Age of 60 years or older;
- Scheduled to undergo cardiac surgery (coronary artery bypass graft and/or valve replacement surgery);
- Provide written informed consents.
Exclusion
- Patients who meet any of the following criteria will be excluded.
- Preoperative history of schizophrenia, epilepsia, Parkinson syndrome, or severe dementia;
- Inability to communicate in the preoperative period because of severe visual/auditory dysfunction or language barrier;
- History of brain injury or neurosurgery;
- Preoperative sick sinus syndrome, severe bradycardia (HR \< 50 bpm), second-degree or above atrioventricular block without pacemaker;
- Severe hepatic dysfunction (Child-Pugh class C);
- Severe renal dysfunction (requirement of renal replacement therapy);
- Other conditions that are considered unsuitable for participation.
Key Trial Info
Start Date :
October 21 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 3 2022
Estimated Enrollment :
285 Patients enrolled
Trial Details
Trial ID
NCT03289325
Start Date
October 21 2021
End Date
May 3 2022
Last Update
October 1 2024
Active Locations (2)
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1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
2
Beijing Fuwai Hospital
Beijing, Beijing Municipality, China, 100037