Status:
RECRUITING
Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Ischemic Stroke
Atheroscleroses, Cerebral
Eligibility:
All Genders
30-85 years
Brief Summary
The study is to attain early recognition of the unstable plaques which have an imminent embolic risk in patients with intracranial atherosclerotic disease (IAD).
Detailed Description
Potential candidates will undergo a cranial MRI and MR angiography. Patients who are found signal void in a relevant intracranial internal carotid artery or middle cerebral artery will proceed to a 30...
Eligibility Criteria
Inclusion
- Inclusion Criteria for the Symptomatic Group:
- Patient is 30 to 85 years of age, inclusive.
- Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD.
- Patient who has no contra-indication for the proposed imaging tests.
- Patient understands the purpose and requirements of the study, and has provided an informed consent.
- Inclusion Criteria for the Asymptomatic Group:
- Patient is 30 to 85 years of age, inclusive.
- Patient who has a high-grade (\>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence.
- Patient has no MES detected on TCD examination.
- Patient who has no contra-indication for the proposed imaging tests.
- Patient understands the purpose and requirements of the study, and has provided an informed consent.
Exclusion
- Subject who meets one or more of the following criteria cannot be recruited in the study:
- Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc.
- A tandem stenosis \>50% at proximal internal carotid artery.
- Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
- A medical condition that would not allow the patient to adhere to the protocol or complete the study.
Key Trial Info
Start Date :
February 1 2010
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT03291652
Start Date
February 1 2010
End Date
December 31 2026
Last Update
February 12 2025
Active Locations (1)
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1
Chinese University of Hong Kong
Hong Kong, Hong Kong