Status:
TERMINATED
Prehabilitation Exercise Plus Perioperative Optimization of Senior Health
Lead Sponsor:
Duke University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Cognitive Decline
Age-Related Memory Disorders
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The purpose of this study is the examine the feasibility of and estimate the efficacy of a preoperative exercise (i.e. prehabilitation) program in 40 up to sedentary older adults (i.e. age 60 and over...
Detailed Description
The purpose of this study is the examine the feasibility of and estimate the efficacy of a preoperative exercise (i.e. prehabilitation) program in 40 up to sedentary older adults (i.e. age 60 and over...
Eligibility Criteria
Inclusion
- Age 60 and above
- Able to speak English.
- seen, scheduled to be seen, or eligible to be seen in Preoperative Optimization of Senior Health (POSH) clinic prior to surgery
- scheduled for general, gynecologic or urologic surgery under the Enhanced Recovery After Surgery (ERAS) protocol, or eligible for ERAS protocol
- Lives within a \~1 hr drive of Duke
- Sedentary (not currently following physical activity guidelines)
- Ambulatory (assistive devices ok)
- Able to give informed consent
- Willing to perform prescribed exercises
Exclusion
- Inmate of a correctional facility (i.e. prisoners).
- Documented or suspected family or personal history of malignant hyperthermia.
- Allergy or other contraindication to receiving isoflurane
- Receiving systemic chemotherapy after the first cognitive testing session and before the 6 wk follow up cognitive testing sessions.
- Major head trauma that occurs after the first cognitive testing session and before the 6 wk follow up cognitive testing sessions.
- Anginal symptoms, known coronary artery disease (CAD), or high cardiovascular risk per American College of Cardiology (ACC)/ American Heart Association (AHA) guidelines
- Taking anticoagulants that would preclude lumbar puncture per the American Society of Regional Anesthesia guidelines.
- Diagnosed history of dementia.
- Inability to ambulate independently.
- Otherwise not appropriate for study participation in the judgement of the Principal Investigator, such as (but not limited to) because the patient does not have the cardiopulmonary capacity to complete the exercise regimen.
Key Trial Info
Start Date :
August 20 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 8 2018
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT03291795
Start Date
August 20 2017
End Date
January 8 2018
Last Update
July 5 2019
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710