Status:
UNKNOWN
Stratification of Chronic Alcoholic Liver Diseases (SCALE Study)
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
Alcoholic Liver Disease
Eligibility:
All Genders
18-80 years
Brief Summary
Recent years, the European Association for the Study of the Liver-chronic liver failure (EASL-CLIF) has defined and graded acute-on-chronic liver failure (ACLF) based on CANONIC study which enrolled c...
Eligibility Criteria
Inclusion
- Long-term alcohol consumption (at least one of the followings):
- \>40g/d for male and \>20g/d for female, at least for 5 years;
- \>50g/d for at least 6 months;
- Liver injury (at least one of the followings):
- AST\>1.0 ULN and AST\>ALT;
- TBIL\>2.0mg/dl;
- Ascites;
- Hepatic encephalopathy;
- Esophageal variceal bleeding;
- Hypersplenism
Exclusion
- Younger than 18 or older than 80;
- Other etiologies rather than alcoholic liver disease, including but not limited to the followings:
- Acute or chronic virologic hepatitis: Hepatitis A-E, Hepatitis caused by CMV,EBV, etc.
- Autoimmune hepatitis, including PSC, PBC, AIH, IgG4 related liver disease
- Inherited metabolic liver diseases: Wilson disease;
- Others: Schistosomiasis
- HIV antibody positive;
- Malignancies including but not limited to HCC;
- Pregnancy;
- Hospital stay less than 24h;
- Refuse to sigh the informed consent;
- Combined with other improper situations determined by investigators.
Key Trial Info
Start Date :
November 16 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 30 2020
Estimated Enrollment :
3000 Patients enrolled
Trial Details
Trial ID
NCT03295812
Start Date
November 16 2017
End Date
December 30 2020
Last Update
January 23 2018
Active Locations (26)
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1
Nanfang Hospital
Guangzhou, Guangdong, China, 510515
2
People's hospital of Yangshan
Qingyuan, Guangdong, China
3
Dongguan dalang hospital
Dongguan, China
4
People's hospital of Foshan Nanhai District
Foshan, China