Status:
COMPLETED
Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points
Lead Sponsor:
West China Hospital
Conditions:
Acupuncture
Knee Osteoarthritis
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The investigators plan to investigate the effectiveness of acupuncture at highly sensitive points, compared with lowly/non-sensitive points or no acupuncture (waiting-list), in improving pain, joint f...
Detailed Description
Participants in the high sensitization group receive acupuncture treatment at the five highly sensitive points; Participants in the low/non-sensitization group receive acupuncture treatment at the fiv...
Eligibility Criteria
Inclusion
- Participants aged 40 years or older and diagnosed with mild or moderate knee osteoarthritis(KOA) are eligible to participate in the study
- The following criteria are used for diagnosis of KOA:
- refractory knee pain for most days in the last month;
- joint space narrowing, sclerosis or cystic change in subchondral bone (as demonstrated in X-ray);
- laboratory examinations of arthritis: clear and viscous synovial fluid (≥2 times) and white blood cell count \< 2000/mm3;
- morning stiffness continues less than 30 minutes;
- bone sound exists when joints was taking flexion and/or extension. If a patient meets criteria 1 and 2, or criteria 1, 3, 4, and 5, a diagnosis of KOA is confirmed.
Exclusion
- Patients will be excluded if they meet any of the following:
- diagnosed with conditions leading to skeletal disorders, such as tuberculosis, tumors or rheumatism of the knee joint and rheumatoid arthritis;
- present sprain or trauma in the lower limb;
- unable to walk properly due to foot deformity or pain;
- present with mental disorders;
- present with comorbidities including severe cardiovascular disease, liver or kidney impairment, immunodeficiency, diabetes mellitus, blood disorder or skin disease;
- females who are pregnant or lactating;
- using physiotherapy treatments for osteoarthritis knee pain;
- have used intra-articular injection of glucocorticoid or viscosupplementation in the past six months;
- received knee-replacement surgery;
- diagnosed with severe (stage 4, according to Kellgren and Lawrence radiographic classification) or late clinical stage of KOA;
- have a swollen knee or positive result of floating patella test; or'
- are participating or have participated in the other clinical trials.
Key Trial Info
Start Date :
October 25 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 20 2020
Estimated Enrollment :
666 Patients enrolled
Trial Details
Trial ID
NCT03299439
Start Date
October 25 2017
End Date
November 20 2020
Last Update
December 30 2021
Active Locations (4)
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1
the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
Zhengzhou, Henan, China, 450003
2
Wuhan Integrated Traditional Chinese Medicine and Western Medicine Hospital
Wuhan, Hubei, China, 430022
3
Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University
Chengdu, Sichuan, China, 610041
4
the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
Chengdu, Sichuan, China, 610075