Status:
COMPLETED
CRF - Nociceptin Receptor Interactions
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Healthy
Eligibility:
All Genders
18-40 years
Phase:
EARLY_PHASE1
Brief Summary
To determine if \[C-11\]NOP-1A receptor binding (VT) can be altered by an intravenous hydrocortisone (cortisol) challenge through CRF-NOP interactions
Detailed Description
Examines changes in \[C-11\]NOP-1A pharmacokinetics caused by an intravenous hydrocortisone challenge (1 mg/kg)
Eligibility Criteria
Inclusion
- Males or females between 18 and 40 years old
Exclusion
- Current DSM-5 psychiatric disorders
- Binge drinking as defined in NIAAA criteria in the past month
- Recreational abuse of opiates, sedative-hypnotics, cocaine, amphetamines, MDMA, and PCP, as well as cannabis use
- Currently on any prescription medical or psychotropic medication;
- Current or past severe medical, endocrine, cardiovascular, immunological or neurological illnesses
- Currently pregnant or breast-feeding;
- History of radioactivity exposure via prior nuclear medicine studies or occupational exposure in past twelve months
- Metallic objects in the body that are contraindicated for MRI;
- First-degree relative with psychosis or mood disorders
Key Trial Info
Start Date :
June 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2019
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT03302416
Start Date
June 1 2016
End Date
June 1 2019
Last Update
October 27 2020
Active Locations (1)
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1
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213