Status:
RECRUITING
The GEOLynch Cohort Study
Lead Sponsor:
Wageningen University
Collaborating Sponsors:
Wereld Kanker Onderzoek Fonds
Dutch Cancer Society
Conditions:
Lynch Syndrome
Neoplasms
Eligibility:
All Genders
18-80 years
Brief Summary
The GEOLynch cohort study has been established to investigate the influence of genetic, environmental and other factors on tumour risk in persons with Lynch syndrome.
Detailed Description
The GEOLynch cohort study includes persons with Lynch syndrome (LS) only. Persons with LS carry an inherited mutation in one of the DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 which increases t...
Eligibility Criteria
Inclusion
- Persons with a known mutation in a gene that causes Lynch syndrome, i.e. with an inherited monoallelic pathogenic germline mutation in either the MLH1, MSH2, MSH6, PMS2 or EPCAM gene.
- Aged between 18 and 80 years at inclusion.
Exclusion
- Additional carrier of another hereditary colon cancer predisposition syndrome (e.g. FAP)
- (Chronic) Inflammatory bowel disease
- Non-Dutch speaking
- Dementia or another mental condition that makes it impossible to fill out questionnaires
- Terminally ill persons
Key Trial Info
Start Date :
July 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03303833
Start Date
July 1 2006
End Date
December 1 2030
Last Update
October 6 2017
Active Locations (1)
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1
Wageningen University
Wageningen, Netherlands