Status:
COMPLETED
Community Dynamics of Malaria Transmission and Mosquito Feeding in Bancoumana, Mali
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Malaria
Eligibility:
All Genders
6-65 years
Brief Summary
Background: Half of the world's population is at risk of malaria. Malaria is a disease that affects many people in Mali and other parts of Africa. It is caused by germs spread by mosquito bites. Mala...
Detailed Description
A vaccine that interrupts malaria transmission is critical to eradicate the disease, but improved assays are needed to measure the efficacy of vaccines. Transmission-blocking vaccines (TBVs) work by i...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- GENOTYPE ONLY COHORT
- Any age
- Known resident of Bancoumana or the surrounding villages
- Acceptance and signature of the written informed consent and the assent for children aged 12-17 years
- Willingness to allow stored laboratory specimens to be used for future research
- PARASITE SURVEILLANCE COHORT
- 6 months to 65 years of age
- Known resident of Bancoumana or the surrounding villages
- Willingness to allow stored laboratory specimens to be used for future research
- Acceptance and signature of the written informed consent and the assent for children aged 12-17 years
- DSF COHORT
- Aged between 5 and 65 years, inclusive
- Good general health as determined by review of medical history and/or clinical testing at the time of screening
- Known resident of Bancoumana or the surrounding villages
- Willingness to allow stored laboratory specimens to be used for future research
- Willingness to undergo DSF
- Acceptance and signature of the written informed consent and the assent for children aged 12-17 years
- EXCLUSION CRITERIA:
- GENOTYPE ONLY COHORT
- Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol
- Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol
- PARASITE SURVEILLANCE CHORT
- Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol
- Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol
- Currently enrolled participant in protocol 17-I-N006 or another active LMIV/MRTC vaccine clinical trial
- DSF COHORT
- Behavioral, cognitive, or psychiatric disease that in the opinion of the investigator affects the ability of the subject to understand and cooperate with the study protocol
- Other condition that, in the opinion of the investigator, would jeopardize the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol
- Currently enrolled participant in protocol 17-I-N006 or another LMIV/MRTC vaccine clinical trial
- History of severe reaction to mosquito bites
Exclusion
Key Trial Info
Start Date :
January 28 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 12 2020
Estimated Enrollment :
1928 Patients enrolled
Trial Details
Trial ID
NCT03304704
Start Date
January 28 2018
End Date
July 12 2020
Last Update
February 10 2025
Active Locations (3)
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1
Bancoumana Malaria Vaccine Center
Bamako, Mali
2
Univ of Sciences, Techniques and Technology
Bamako, Mali
3
Doneguebougou Facility
Donéguébougou, Mali