Status:
COMPLETED
The Influence of Cholecystectomy on Secretion of Incretin Hormones
Lead Sponsor:
University Hospital, Gentofte, Copenhagen
Conditions:
Glucose Metabolism Disorders
Eligibility:
All Genders
18-80 years
Brief Summary
The effect of cholecystectomy on postprandial plasma GLP-1 responses (primary endpoint) and glucose metabolism will be evaluated in 30 patients planned to undergo elective laparoscopic cholecystectomy...
Detailed Description
This is an observational, parallel-group study in 30 patients with gallstone disease and 10 healthy control subjects. In patients undergoing cholecystectomy a 4h-meal test (liquid mixed meal) will be ...
Eligibility Criteria
Inclusion
- caucasians above 18 years of age, having an elective cholecystectomy performed because of gallstone disease.
- normal fasting plasma glucose and HbA1c
- normal hgb
- Normal gallbladder ejection fraction
Exclusion
- liver disease
- kidney disease
- diabetes
- ongoing infection
- abdominal pain not related to gall stones
- BMI \<18,5 kg/m2 eller BMI \>30 kg/m2
- prior abdominal surgery
Key Trial Info
Start Date :
November 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03305783
Start Date
November 1 2017
End Date
April 1 2022
Last Update
February 9 2023
Active Locations (1)
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1
Center for Clinical Metabolic Research
Copenhagen, Hellerup, Denmark, 2900