Status:
COMPLETED
Post Prandial High Resolution Impedance- Manometry
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Gastro-esophageal Reflux
Eligibility:
All Genders
18+ years
Brief Summary
Nine to 30% of the population suffers from gastro-esophageal reflux disease (GERD) - suggestive symptoms (heartburn, regurgitation, chest pain, chronic couch, sore throat). Proton pump inhibitor (PPI)...
Eligibility Criteria
Inclusion
- Patient of both gender older than 18 years
- Patient referred for post prandial esophageal high resolution manometry combined with impedance and ambulatory 24-h pH-impedance monitoring on proton pump inhibitor
- Heartburn and/or regurgitation despite double dose proton pump inhibitor therapy
- Proven Gastro-esophageal reflux disease off proton pump inhibitor (Los Angeles grade B, C or D esophagitis and/or esophageal acid exposure \> 5% on esophageal pH monitoring off proton pump inhibitor)
- Absence of major esophageal motility disorders (achalasia, esophago-gastric junction outflow obstruction, esophageal spasm, jackhammer esophagus, absent contractions)
- Patient who does not decline to participate to the study
Exclusion
- Patient younger than 18 years
- Pregnancy or breast feeding
- Previous history of esophago-gastric surgery ( including anti-reflux surgery, Heller myotomy, bariatric surgery)
- Patient with severe renal insufficiency
- Patient with severe cardiac insufficiency
- Patient legally incompetent or unable to give consent
- Patient who declines to participate to the study
- Participation to another study at the same time
Key Trial Info
Start Date :
December 21 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 27 2023
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT03306485
Start Date
December 21 2017
End Date
February 27 2023
Last Update
March 30 2023
Active Locations (1)
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1
Exploration Fonctionnelle Digestive, Hôpital Edouard Herriot, Lyon, France
Lyon, France, 69437