Status:
UNKNOWN
Mechanism of Drug-drug Interaction Between Salvianolate Injection and Aspirin
Lead Sponsor:
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Conditions:
Angina, Stable
Eligibility:
All Genders
35-65 years
Phase:
NA
Brief Summary
The combination of anti-platelet medicine treatment and Chinese traditional medicine (TCM) promoting blood circulation to removing blood stasis is widely used in treatment for cardiovascular disease. ...
Eligibility Criteria
Inclusion
- Meet the diagnostic criteria of coronary heart disease.
- Meet the diagnostic criteria of stable angina pectoris.
- Meet the diagnostic criteria of syndrome of blood stasis.
- Angina in grade I-II according to Canadian cardiovascular society (CCS).
- It could be enrolled if the subject taking aspirin or salvianolate injection with one month regularly。
- The subjects were informed and voluntarily signed informed consent.
Exclusion
- Severe heart disease (acute myocardial infarction of acute myocardial infarction in 6 months), severe cardiopulmonary dysfunction (eg: cardiac function II)
- Poorly controlled hypertension(systolic pressure \>160mmHg or diastolic pressure \>100mmHg).
- Diabetics.
- Severe primary diseases such as liver and renal hematopoietic system damage. Such as:liver function（ALT≥2×ULN、AST≥2×ULN）,kidney function（Cr\>1.0×ULN) or nervous and mental disorder.
- Pregnant, breast-feeding and menstrual women, or women planning pregnancy within 3 months.
- Subjects who participated in clinical trials in recent 3 months.
- Subjects who took surgery treatment or had hemorrhagic tendency in recent 4 weeks.
- Subjects who had drug allergy history or with allergic constitution.
- Subjects who has mental or physical disorders.
- Subjects who had bad compliance or is not suitable for this clinical trial by investigator's judgement
Key Trial Info
Start Date :
October 10 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 10 2018
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT03306550
Start Date
October 10 2017
End Date
October 10 2018
Last Update
October 11 2017
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